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KMID : 0369819950250040331
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 4 p.331 ~ p.338
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Adsorption of Presevatives by Sucralfate, Neusilin and Hydrotalcite in Suspension
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Abstract
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In order to screen appropriate preservatives for the suspension containing sucralfate, neusilin and hydrotalcite, the patterns and mechanism of the adsorption and desorption of several preservatives on the antacids were studied. The employed
preservatives were parabens(methyl, propyl, butyl), chlorhexidine diacetate and sorbic acid. While none of parabens were absorbed on three antacids, chlorhexidine diacetate was strongly adsorbed on all the antacids employed, especially on
hydrotalcite.
Sorbic acid was not adsorbed on nesilin and hydrotalcite, however, 65% of sorbic acid was adsorbed on sucralfate. The adsorption of chlorhexidine diacetate on neusilin and hydrotalcite was partly physical and partly chemical, while its adsorption
on
sucralfate was almost chemical. Sorbic acid was completely desorbed from sucralfate. In all cases, the adsorption isotherms were fitted well to both Freundlich equation and Langmuir equation. Based on these results, parabens and sorbic acid were
the
preservatives of choice for the suspension containing sucralfate, neusilin and hydrotalcite.
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